No big deal. More steroid in premed not very welcome but lorazepam helped. IV furosemide provided main daily activity.

So now we wait. The old cells are dying and I’ll get sicker as they go but the new ones are in to grow and eventually take over. Wait. Wait.

Good news last night: Combination of dexamethasone, ondansetron, and aprepitant (had to look that last one up) worked perfectly to prevent any nausea at all.

Bad news: That was 12mg of dexamethasone, and even though it made me less jumpy than did my traditional doses I appreciated getting swacked by some lorazepam. The dex morning-after effect seems minimal.

So the worst parts were operating the flaky cable TV box and keeping my mouth full of crushed ice for a couple of hours during the melphalan infusion. The ice has actually been demonstrated to greatly reduce the later incidence of mouth ulcers, presumably by reducing mucosal delivery of the drug. I was a good boy and so got a little chilled. I’m assured the return on investment is huge.

My night nurse was a Xavier alumna only a few years ahead of Katrina. We got to talking about teachers and I inevitably brought up Mrs. Rickle and wound up showing her Merry’s YouTube of White Rabbit.

Again, they’re not going to wait for my blood counts to completely crash but will instead give me back stem cells tomorrow. Thus the nadir on the counts and the peak of misery, which should begin early next week, may only last a very few days if I get good engraftment. Today is likely to be very uneventful, and the rest of the week pretty much the same.

My home for the next couple of weeks is reasonably pleasant and looks to have better video streaming than I could get down in pheresis. How cool is that?

“The deep breath before the plunge.” There was a time at the beginning of WWII known in Britain as the Phony War and in Germany as the Sitzkreig. My stem cell collection went so well last week that we had several days of freedom to make sure everything is prepared, then sit and contemplate what’s coming.

Today we wait for the Mayo hospital to tell us there is a bed ready, at which point I go in for paperwork, processing, and getting settled. Then I have some hours of hydration and loading with antiemetics in preparation for a single fatal dose of melphalan tonight. They won’t wait for full effects of the poison but rather have scheduled rescue infusion of half my stem cell collection (that half is nearly twice what is usually needed for engraftment) on Wednesday. That will be Day Zero of my new life. The other half of the collected cells will stay in the freezer, perhaps to be used for yet another rebirth some years down the road.

Yes I am afraid. Yes I have made the right choices. Like going to Caltech, this will be a good thing to have done. And the odds are considerably more in my favor than they were then. And if things don’t go perfectly it certainly won’t be for lack of loving support. I thank you again for all the prayers and good wishes.

My counts were good enough to start collecting today. That means that so far about every single thing has gone a little better than expected (and a lot better than feared). Though I’ll be spending hours here over the next few days I’ll probably not have anything new to report so if I don’t post any more just assume things continue to go well.

They want two hours to be sure I don’t bleed or keel over for some other reason. Nancy already brought me some chocolate milk from the cafeteria to break my fast. All is well. The catheter went in IJ so I didn’t need as much sedation as I’d feared; I believe I was largely conscious the whole time though definitely relaxed. No problem that I forgot to bring my OSA jaw support appliance.

And now the local is starting to wear off where the tunnel crossed the clavicle. Ah, well. I just may enjoy some narcotic come bedtime.

You guys wanted updates, you’re getting updates. I believe I can restrain myself from describing each bowel event when they become the center of my life next week.

Today I get my second dose of Neupogen. They say I’ve a 20% chance of unpleasant side effects when it really kicks in with later doses but for now all is well.

Tomorrow I get my central venous catheter. It has two honking big lumens for pheresis so I’ll probably get some sedation. If I don’t remember the procedure it couldn’t have been too bad, right?

Thank you for all the warm thoughts and prayers.