A little bit of headache with a drop in temperature this afternoon resolved with some fluids. No other signs of CRS or anything else for that matter. We anticipate a minor moment of truth tomorrow or the next day, but I suspect the toci will pretty thoroughly mask any trouble, if any.

We are told the occurrence of CRS after the second dose is not predictive of any more such events. Some 90% of previous patients had at least one mild bout of CRS – some after the first dose, many more after the second, a few less after the third, and very few thereafter. The N of the study and subsequent experience are still not high enough to draw a lot of conclusions. However, reason, and some limited experience, do suggest that the presence of a reaction is a good sign that *something* is happening. This is a great comfort to those of us whose greatest fear is that the treatment won’t work.